Optimized emulsion e1 and e4 were used for preparation of emulgel. However, cmz showed a considerable degradation on longterm storage in the developed microemulsion based gel which was attributed to. In this study novel microemulsion based gels with poloxamer 182 as a surfactant were designed and investigated as potential carriers for topical dosage forms with naproxen, nonsteroidal antiinflammatory drug. Pdf microemulsion based bioadhesive gel of itraconazole. Pdf microemulsions, which are optically isotropic and thermodynamically stable systems of water, oil, surfactant, andor cosurfactant, have. The microemulsion is stabilized by means of the surfactant. The most widely used class of enzymes in microemulsion based reactions is of lipases 57. Formulation and characterization of microemulsion based gel of. Gupta faculty of pharmacy, dehradun institute of technology, dehradun, uttarakhand, india are cited, but the list is by no means exhaustive. Nimesulide has extensively used for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old and in the treatment of rheumatoid arthritis and inflammatory conditions. The optimized microemulgel f1 showed acceptable physical properties with lowest viscosity value 2325 cps and showed pseudoplastic behaviour, highest spreadability value 3. Jul 02, 2011 stability study on the selected ctm microemulsion liquid and gel. Microemulsion in enhanced oil recovery, detergency, cosmetics, agrochemicals, food. The objective of the present investigation was to develop and evaluate microemulsion based gel for the vaginal delivery of clotrimazole cmz.
Gelbased microemulsion design and evaluation for topical. When gel and microemulsion are used in combined form and the dosage forms are referred as microemulsion based gel. Aug 24, 2017 clotrimazole microemulsion and microemulsion. Microemulsion based gels have emerged as one of the most intresting topical drug delivery system as it has dual control release system i. Gellike microemulsion, amphotericin b, topical delivery, cutaneous leishmaniasis. Microemulsion based bioadhesive gel of itraconazole using tamarind gum. They offer numerous advantages like improved solubilization of both hydrophilic and lipophilic drugs, better bioavailability, prolong and targeted release, enhanced permeation across biological membranes, protection against oxidation, better stability and ease of manufacturing as well as. Development and evaluation of microemulsion based gel mbgs containing econazole nitrate for nail fungal infection article pdf available in journal of pharmacy research 201254. Novel isotretinoin microemulsionbased gel for targeted. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution.
The irritancy of formulation was determined based on the method described by draize et al. Patil department of pharmaceutics, mets institute of pharmacy, bhujbal knowledge city, adgaon, nashik, india abstract background. Thermoresponsive nanoemulsionbased gel synthesized. In microemulsion based gel the reduction of drug particle size to the micron range. Formulation and characterization of microemulsion based. Pdf development and evaluation of microemulsion based. Pdf microemulsionbased vaginal gel of clotrimazole. Development and evaluation of microemulsion based gel mbgs containing econazole nitrate for nail fungal infection. The buffer in the reservoir compartment was stirred continuously at a constant speed. Pdf formulation and characterization of clotrimazole.
Quality by design qbd approach for optimization of. The results indicated that cxb microemulsionbased gel had better bioavailability than celebrex. They offer numerous advantages like improved solubilization of both hydrophilic and lipophilic drugs, better bioavailability, prolong and targeted release, enhanced permeation across biological membranes, protection against. Formulation and evaluation of microemulsion based gel of. Novel isotretinoin microemulsionbased gel for targeted topical therapy of acne. Microemulsionbased novel transdermal delivery system of.
Aliquots were withdrawn and were suitably diluted, filtered if needed and then injected into hplc perkin elmer for analysis of drug content. Microemulsions based transdermal drug delivery systems. Formulation, development and evaluation of etoricoxib. Also the small size of the drug droplets in microemulsion yields large interfacial area, from which the drug can. Carbopol 971p and hpmc k100m were used as independent variables. Microemulsion based novel transdermal delivery system of tetramethylpyrazine. For enhancing the viscosity, carbopol was used to form an me based gel. Microemulsion based gel of sulconazole nitrate for topical application.
Based on results of previous studies, liquid and gel formulations of m3 and m4 were stored in wellstoppered dark brown glass containers for 6 months at 40c and 75% relative humidity. Formulation development, in vitro and in vivo evaluation of. Microemulsion based gel was evaluated for invitro as well as exvivo parameters. Pdf formulation of nimesulide microemulsion based hydrogel.
Microemulsion formation is spontaneous and does not require much energy. Lavjot kaur, rakesh kumar, deepak kumar rahi and vivek ranjan sinha affiliation. Original article formulation and evaluation of microemulsion. The term microemulsion refers to a thermodynamically stable, isotropic clear. Formulation and characterization of microemulsion based gel. Pdf development and evaluation of microemulsion based gel. Microemulsion based gel of voriconazole broadspectrum antifungal agent could be an effective strategy for treatment of topical fungal infections. These higher viscosity systems are more suitable for topical administration.
Design, development, and optimization of dexibuprofen. Two microemulsion were selected based on the globule area, pdi and physical stability and incorporated into the gel base of sodium alginate. Phospholipid microemulsionbased hydrogel for enhanced topical delivery of lidocaine and prilocaine. Design and study of poloxamerbased microemulsion gels with. A recent approach for topical drug delivery system article pdf available in research journal of pharmacy and technology 82.
The aim of the present study was to investigate the potential of a nanoemulsion formulation for topical delivery of aceclofenac. Microemulsion as a vehicle for transdermal permeation of nimesulide. Oil and water are immiscible and they separate into two phases when mixed, each saturated with traces of the other component capek, 1999. It is more advantageous as compared to conventional topical formulations. Microemulsion was evaluated for globule size fesem, zetasizer, % transmittance, ph, viscosity, conductivity etc. Antiinflammatory agents are widely used to relieve inflammation caused by various factors. A microemulsion me was prepared using caprylocaproyl polyoxyl8 glycerides, diethylene glycol monoethyl ether, and propylene glycol monolaurate. So based on the stability, e1 and e4 were selected as optimized emulsion. Nanoemulsion and nanoemulgel as a topical formulation. Formulation, characterization, and clinical evaluation of. Moreover, microemulsion based gel limits the absorption of drug in systemic circulation and provides higher drug accumulation in the skin for efficient action 10. Evaluation of a microemulsionbased gel formulation for topical drug. Pharmaceutical compositions derived from microemulsion based gels. Evaluation of microemulsion based hydrogel globule size determination the average droplet size of samples was measured at 25c by malvern zeta sizer.
To deliver 2,3,5,6tetramethylpyrazine tmp in a relatively. Hence, the developed phospholipid microemulsion based gel formulation has been proposed as more useful alternative for the topical delivery of lidocaine and prilocaine. The microemulsion based gel could be successfully developed for the vaginal delivery of clotrimazole. Lecithinlinker microemulsion based gels for drug delivery xiao yue xuan master of applied science department of chemical engineering and applied chemistry university of toronto 2011 abstract microemulsions have gained interest from the pharmaceutical industry due to their ability to co. To overcome the above drawback, the low viscous microemulsions were added to viscous gel bases to potentiate its applications as topical drug delivery systems so that various drug related toxic effects and erratic drug absorption can be avoided. Microemulsion is a nanoparticle synthesis technique in which two immiscible fluids such as water in oil wo, oil in water ow or water in supercritical carbon dioxide wsc co2 are thermodynamically stabilized with the aid of a surfactant.
Luliconazole emulsion equivalent to 1g was added to gel matrix of sodium alginate using magnetic stirrer to remove any formation. Phospholipid microemulsionbased hydrogel for enhanced. It is characteristic that a gelatinizer and water are added to the microemulsion thereby bringing the microemulsion into a gel form. The nanoemulsion area was identified by constructing pseudoternary phase diagrams. The aim of the present study was to design nanocarriers for the topical application of rivastigmine. The developed gel showed promising in vitro performance with respect to bioadhesivity and antifungal activity. Evaluation of a microemulsionbased gel formulation for. Nanoemulsionbased gel formulation of aceclofenac for topical. Various oilinwater nanoemulsions were prepared by the spontaneous emulsification method.
The prepared nanoemulsions were subjected to different thermodynamic stability tests. University institute of pharmaceutical sciences, panjab university, chandigarh 160 014, university institute of pharmaceutical sciences, panjab university, chandigarh 160 014, department. The bioadhesive potential and antifungal activity of the cmz microemulsionbased gel cmzmbg was determined in comparison to the marketed clotrimazole gel candidv gel by in vitro methods. Hence, the formulation of cxb was selected for sol to find out suitable formulation for microemulsion, the solubility of cxb in triacetin oil phase, tween 80 surfactant, and transcutolp cosurfactant was screened respectively and optimized. Formulation and evaluation of microemulsion based topical. Optimization of microemulsion based transdermal gel of. The oilinwater microemulsion is first prepared and evaluated and then incorporated into a gel base and this dosage form is referred to a microemulsion based gel.
The microemulsion region computed was comparable to the findings of chen et al. Thermoresponsive nanoemulsionbased gel synthesized through a. Design of experiment was used to optimize microemulsion based gel. However, low viscosity of microemulsion restrains its applicability in pharmaceutical industry. Its observe solubility in oil, surfactant and cosurfactant and having diameter in the range of 100a 10100 nm. The solubility of cmz in oils and surfactants was evaluated to identify components of the microemulsion. The microemulsion region is presented in the diagram and rest of the region represents formation of emulsion or gel. The use of micro emulsion based gels can be extended in analgesics and antifungal drugs.
The bioadhesive potential and antifungal activity of the cmz microemulsion based gel cmzmbg was determined in comparison to the marketed clotrimazole gel candidv gel by in vitro methods. Apr 10, 2017 the aim of the current research was to investigate the release of diclofenac sodium, a poorly watersoluble drug from different formulations in vitro. Microemulsions can improve skin penetration of lycopene. Approximately two third of population throughout the world is affected by a common fungal infection1. Novel gellike microemulsion for topical delivery of amphotericin b. Us6004580a pharmaceutical compositions derived from. Lower irritation microemulsionbased rotigotine gel.
1364 99 201 1515 913 347 1363 111 1163 21 81 162 1559 1206 485 978 234 1260 1571 546 1347 634 1061 1134 1010 598 1384 1034 328 331 1195 416 438 664 1317 251 583 1072 1410 329 1305 249 302 1444 622 1098 1363